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. 2014 Dec 5;7:63. doi: 10.1186/s12920-014-0063-z

Table 4.

Genomic segments significantly over- or under-expressed

a) DS AMKL vs. normal CB MK
Chr and location a Segment start b Segment end b 'A'/'E' ratio q-value Genes in the segment c
Over-expressed segments
chr3 3q22.1 130,000,001 130,500,000 80.36 0.00015 COL6A5 + COL6A6 + Hs.596709+ Hs.596805+ PIK3R4-
Under-expressed segments
chr7 7q11.23 77,000,001 77,500,000 0.48 0.00117 GSAP - PTPN12 - LOC101059910- RSBN1L-AS1- RSBN1L- Hs.594486- Hs.720279- TMEM60- PHTF2-
chr4 4q12-q21 74,750,001 75,250,000 0.37 0.00119 PF4 - PPBP - CXCL5- CXCL3 - CXCL2- MTHFD2L- Hs.662627- EREG-
chr4 4q32.1 156,250,001 156,750,000 0.12 0.00000 MAP9 - GUCY1A3 - Hs.612374 - GUCY1B3 -
b) Non-DS AMKL vs. normal CB MK
Chr and location Segment start Segment end 'B'/'E' ratio q-value Genes in the segment
Over-expressed segments
chr3 3q22.1 130,000,001 130,500,000 116.13 0.00030 COL6A5 + COL6A6 + Hs.596709+ Hs.596805+ PIK3R4-
chr11 11p15 6,750,001 7,250,000 50.98 0.00117 OR6A2+ OR10A5 + OR10A4 + ZNF215- ZNF214- Hs.445849+ NLRP14+ RBMXL2- LOC100506238+
Under-expressed segments
chr4 4q12-q21 74,750,001 75,250,000 0.42 0.00003 PF4 - PPBP - CXCL5 - CXCL3 - CXCL2- MTHFD2L- Hs.662627- EREG-

Data refer to the following comparisons: a) DS AMKL (pool 'A') vs. normal CB MK (pool 'E'); b) non-DS AMKL (pool 'B') vs. normal CB MK (pool 'E'). Analysis was performed using default parameters (see Methods section). Segments are sorted by increasing 'A'/'E' ratio in a), 'B'/'E' ratio in b). In the "Map" mode, TRAM displays UniGene EST clusters (with the prefix "Hs." in the case of H. sapiens) only if they have an expression value. Some segments are not shown for simplicity because they are over-lapping with those highlighted in one of the listed regions. The complete results for this model are available as on line additional material.

aChr: chromosome. The segment location cytoband was derived from that of the first mapped gene within the segment.

bSegment Start/End: chromosomal coordinates for each segment.

cBold and '+': over-expressed gene; bold and '-': under-expressed gene; '+' or '-': gene expression value higher or lower than the median value, respectively.