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. 2014 Dec 31;33(1):113. doi: 10.1186/s13046-014-0113-6

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© Zhang et al.; licensee BioMed Central. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Downregualtion of miR-301a suppressed CRC cell invasion and lung metastases in vivo . (A) miR-301a inhibited CRC cell invasion. H&E staining of tumor acquied from nude mice bearing the SW620/LV-anti-miR-301a or SW620/LV-anti-miR-NC cells (indicated by arrows), 4 weeks post implantation. (B) Mean lung metastatic nodules (left) and histologic analysis (H&E staining) of lung (right) 7 weeks post implantation. Metastatic tumor lesions are indicated by arrows. Data were represented as means ± SD. Magnification, ×200. Scale bars, 100 μm. *, P < 0.05.