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. 2014 Dec 31;33(1):113. doi: 10.1186/s13046-014-0113-6

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© Zhang et al.; licensee BioMed Central. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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miR-301a regulated metastasis and invasion through suppressing TGFBR2 in CRC cells. (A) Western bloting showed TGFBR2 was downregulated in SW480 cells transiently transfected with TGFBR2 siRNA. (B) The cell invasion and migration ability were improved in TGFBR2 downregulated SW480 cells. (C) Expression of TGFBR2 protein in SW620/LV-anti-miR-301a or SW620/LV-anti-miR-NC cells transiently transfected with TGFBR2 siRNA or siRNA/NC. (D) Cell invasion and migration assays of SW620/LV-anti-miR-301a or SW620/LV-anti-miR-NC cells transiently transfected with TGFBR2 siRNA or siRNA/NC. Data were representedas means ± SD from 3 independent experiments. **, P < 0.01.