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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Free Radic Biol Med. 2014 Sep 16;77:183–194. doi: 10.1016/j.freeradbiomed.2014.08.030

Fig. 1. Binge alcohol increasedCYP2E1 and hypoxia in mice.

Fig. 1

(A,B) The changes of BAC (A) and plasma ALT (B) after binge alcohol exposure.(C) Representative H&E staining of livers at 9 h after the last ethanol dose. (D) Immunoblot analysis of CYP2E1in whole liver lysates.(E) CYP2E1αctivityin cytoplasm.(F) Representative immunohistochemicalstainings(arrows) of CYP2E1 and pimonidazole in livers at 6 h (i.e., 30 h from the first ethanol dose). PC, pericentral regions. Data (n=4/group) expressed as means ± SE(*p< 0.05 and **p< 0.01).