TABLE I.
Activity of PR-104A Against Cell Lines in the PPTP In Vitro Panel Under Aerobic Conditions
| Cell line | Histology | IC50 (μM) |
|---|---|---|
| RD | Rhabdomyosarcoma | 23.1 |
| Rh41 | Rhabdomyosarcoma | 46.6 |
| Rh18 | Rhabdomyosarcoma | >100 |
| Rh30 | Rhabdomyosarcoma | 18.6 |
| BT-12 | Rhabdoid | 39.3 |
| CHLA-266 | Rhabdoid | 26.9 |
| TC-71 | Ewing sarcoma | 6.0 |
| CHLA-9 | Ewing sarcoma | 11.7 |
| CHLA-10 | Ewing sarcoma | 17.4 |
| CHLA-258 | Ewing sarcoma | 16.6 |
| GBM2 | Glioblastoma | 16.5 |
| NB-1643 | Neuroblastoma | 6.4 |
| NB-EBc1 | Neuroblastoma | 5.1 |
| CHLA-90 | Neuroblastoma | >100 |
| CHLA-136 | Neuroblastoma | 18.5 |
| NALM-6 | ALL | 4.6 |
| COG-LL-317 | ALL | 1.7 |
| RS4;11 | ALL | 4.0 |
| MOLT-4 | ALL | 2.4 |
| CCRF-CEM | ALL | 1.4 |
| Kasumi-1 | AML | 27.6 |
| Karpas-299 | ALCL | 24.9 |
| Ramos-RA1 | NHL | 10.1 |
| Median | 16.6 | |
| Minimum | 1.4 | |
| Maximum | >100 |