TABLE IV.
Non-Compartmental Pharmacokinetic Parameters of PR-104 Metabolites in Non-Tumoredscid−/− Mice Administered i.p. at 270 mg/kg
| Species | SCID mice AUC (μM h) | SCID mice Cmax (μM) | SCID mice t½ (min) | Human AUC (μM h) |
|---|---|---|---|---|
| PR-104 | 74.6 | 136.9 | 7.80 | 19.0 |
| PR-104A | 44.5 | 62.0 | 12.8 | 34.9 |
| PR-104S | 10.6 | 11.3 | 19.7 | 0.78 |
| PR-104G | 5.91 | 8.92 | 13.1 | 44.6 |
| PR-104H | 0.534 | 0.723 | 15.5 | 1.75 |
| PR-104M | 0.368 | 0.518 | 16.0 | 0.29 |
Comparison is made to systemic exposures in humans at the PR-104 MTD (1,100 mg/m2 as a 60-min intravenous infusion) [24].