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. Author manuscript; available in PMC: 2015 Jan 23.
Published in final edited form as: Gut. 2011 Apr 6;60(10):1379–1388. doi: 10.1136/gut.2010.226175

Figure 4.

Figure 4

Acinar cell apoptosis was prominent in PACE-trypon mice. (A) Homozygous PACE-trypon mice displayed dramatically increased numbers of TUNEL (terminal deoxynucleotidyl transferase dUTP nick end labelling)-positive cells in comparison with heterozygous animals and controls 7 days (7d) after maximal-rapid induction with tamoxifen (TMmax; 200×). (B) Quantification of apoptotic cells revealed a >15-fold increase of apoptotic cells in comparison with control (n=5, p<0.001). (C) Homozygous PACE-trypon mice showed rapid induction of caspase-3 cleavage as revealed by immunohistochemistry (200×). (D) Caspase-3-positive cells increased 10- (3–5 days) to 30-fold (7 days) in homozygous PACE-trypon mice in comparison with control (n=5, p<0.05 and p<0.001).