Figure 7.

Diphtheria toxin (DT)-induced acinar cell apoptosis caused acute inflammation and fatty replacement. (A) DT administration did not have any deleterious effects on controls (100×). (B) In contrast, DT caused acinar cell apoptosis and acute inflammation in DTR^on mice by 3 days (3d; 100×). (C) Abundant inflammatory cell infiltration and fatty replacement of lost acinar cells were observed at 7 days (7d; 100×). (D) Similar to our long-term findings in PACE-tryp^on mice, fibrosis did not develop in these mice and lost acinar cells were replaced by adipocytes (30d) (100×).