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. 2014 Nov 24;97(2):379–390. doi: 10.1189/jlb.4A0714-339R

Figure 3. The presence of lp36 promotes an increase in IDO-expressing mDCs.

Figure 3.

Human PBMCs were coincubated for 12 h at 37°C with B. burgdorferi at a MOI of 10. Cells were immunostained, and FACS was used to assess the percentage of IDO-expressing CD11c+CD14− cells in unstimulated PBMCs (Medium; white bar) or after coincubation with B31-A3 (black bar), A3-M9 lp36− (white bar), and A3-M9 lp36−/lp36+ (gray bar). Statistical analysis was performed by use of a one-way ANOVA with Tukey-Kramer’s post-test. ***P < 0.001, relative to PBMCs incubated with medium alone. Four hundred thousand events/sample were collected.