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Degradation of cell wall by lytic transglycosylases (LTases) in the periplasm leads to the formation of muropeptides, which are internalized by the permease AmpG. The internalized muropeptides serve as the substrate for NagZ, which removes the NAG moiety from the muropeptide to initiate recycling of the muropeptide and also gene derepression for the onset of antibiotic resistance.
