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. 2014 Dec 4;6(1):155–162. doi: 10.1021/cn500262x

Figure 1.

Figure 1

Maximal rates of dopamine (DA) uptake (Vmax) are positively correlated with the app. Km of psychostimulants at the dopamine transporter (DAT). DAT transgenic overexpressing mice (A, DAT-tg) and rats that had undergone MPH self-administration (B) were used to determine the effects of increased DAT on the app. Km of psychostimulants. Correlational analysis was run to compare the predrug measure of Vmax with the app. Km (app. Km) of dopamine uptake inhibition for methylphenidate (MPH; red; 30 μM; MPH, n = 11; DAT-tg, n = 10), amphetamine (AMPH; green; 10 μM; MPH, n = 9; DAT-tg, n = 9) and cocaine (blue; 30 μM; MPH, n = 9; DAT-tg, n = 9). Regression lines of AMPH, MPH, and cocaine were compared to determine if the range over which increases in Vmax increased app. Km was similar. The extent to which increased Vmax augmented app. Km was different between MPH and AMPH as compared to cocaine. ***p < 0.001.