Figure 3.
No relationship between drug effects on dopamine release and drug effects on dopamine uptake. Correlational analysis was run in order to confirm that evoked dopamine release was not influencing drug induced uptake inhibition. Evoked dopamine release in the presence of drug was correlated with the app. Km of the psychostimulants methylphenidate (MPH; 30 μM; MPH, n = 11; DAT-tg, n = 10), cocaine (30 μM; MPH, n = 9; DAT-tg, n = 9), and amphetamine (AMPH; 10 μM; MPH, n = 9; DAT-tg, n = 9) (A) in transgenic DAT overexpressing mice (DAT-tg) or (B) following MPH self-administration.