Summary of the amplitude of evoked responses (average ± SEM)
at the E1 (red) and E2 (blue) locations without microdialysis probes
(n = 5) and 24 h after probes were implanted and
perfused with DEX (n = 6). The evoked response at
the E1 location after perfusion with aCSF was nondetectable, so the
aCSF results were excluded from the statistical analysis. Statistical
analysis was performed by two-way ANOVA with location (E1, E2, repeated
measure) and probe (no probe, probe with DEX) as the factors. Location
is not a significant factor (F(1,9) = 1.99, p > 0.05). Probe is a significant factor (F(1,9) = 9.08, p < 0.05). Interaction between
factors is significant (F(1,9) = 8.91, p < 0.05). Post hoc pairwise comparisons with Bonferroni corrections
showed that in the presence of DEX the response amplitude at the E1
location is significantly smaller compared to the amplitude at E1
with no probe (***p < 0.0005) and compared to
the amplitude at E2 (*p < 0.05). A separate one-sample t test shows that the response amplitude at E1 after 24
h of perfusion with DEX was significantly elevated above zero t(5) = 3.33, p < 0.05 (aCSF group).