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Reactions catalyzed by deubiquitinases (DUBs). (A) Mature ubiquitin is generated following DUB cleavage. (B) DUBs recycle ubiquitin on proteins destined for degradation by the 26S proteasome. (C) DUBs deubiquitinate substrate proteins. (D) DUBs regulate ubiquitin chain editing.
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