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. 2015 Jan 17;9:575–601. doi: 10.2147/DDDT.S75221

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© 2015 Wang et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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ALS regulates the expression of the key EMT markers in PANC-1 cells.

Notes: Cells were treated with ALS at concentrations of 0.1 μM, 1 μM, and 5 μM for 24 hours and then protein samples were subject to Western blotting assay. Bar graphs showing the relative expression level of E-cadherin, N-cadherin, snail, slug, TCF-8/ZEB1, vimentin, β-catenin, ZO-1, and claudin 1 in PANC-1 cells. Data represent the mean ± SD of three independent experiments. *P<0.05 and **P<0.01 by one-way ANOVA.

Abbreviations: ALS, alisertib; EMT, epithelial-to-mesenchymal transition; SD, standard deviation; ANOVA, analysis of variance.