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. 2015 Jan 17;9:575–601. doi: 10.2147/DDDT.S75221

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© 2015 Wang et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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ALS induces cell cycle arrest in G₂/M phase in PANC-1 and BxPC-3 cells.

Notes: Cells were treated with ALS at concentrations of 0.1 μM, 1 μM, and 5 μM for 24 hours or 5 μM over 72 hours. Then, cells were subject to flow cytometry analysis. (A) Histographs of cell cycle distribution of PANC-1 and BxPC-3 cells treated with ALS at 0.1 μM, 1 μM, and 5 μM for 24 hours. (B) Bar graphs showing the percentage of PANC-1 and BxPC-3 cells in G₁, S, and G₂/M phase when treated with ALS at 0.1 μM, 1 μM, and 5 μM for 24 hours. (C) Histographs of cell cycle distribution of PANC-1 and BxPC-3 cells treated with 5 μM ALS over 72 hours. (D) Bar graphs showing the percentage of PANC-1 and BxPC-3 cells in G₁, S, and G₂/M phase when treated with 5 μM ALS over 72 hours.

Abbreviation: ALS, alisertib.