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. 2015 Jan 17;9:575–601. doi: 10.2147/DDDT.S75221

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© 2015 Wang et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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ALS induces autophagic cell death in PANC-1 and BxPC-3 cells.

Notes: Cells were treated with ALS at concentrations of 0.1 μM, 1 μM, and 5 μM for 24 hours and cell samples were subject to flow cytometry analysis and confocal microscopic examination. (A) Flow cytometric plots of PANC-1 and BxPC-3 cells. (B) Bar graphs showing percentage of autophagic cells in PANC-1 and BxPC-3 cells quantified by flow cytometry. (C) Confocal microscopic images showing the autophagy in PANC-1 and BxPC-3 cells. (D) Bar graphs showing the percentage of autophagic PANC-1 and BxPC-3 cells examined by confocal microscopy. Magnification, ×60; scale bar, 5 μM. Data represent the mean ± SD of three independent experiments. *P<0.05, **P<0.01, and ***P<0.001 by one-way ANOVA.

Abbreviations: ALS, alisertib; SD, standard deviation; ANOVA, analysis of variance.