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. 2015 Jan 17;9:575–601. doi: 10.2147/DDDT.S75221

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© 2015 Wang et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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ALS modulates the expression and phosphorylation levels of PI3K, AMPK, p38 MAPK, Akt, Erk1/2, mTOR, PTEN, beclin 1, and LC3-II/I in BxPC-3 cells.

Notes: Bar graphs showing the ratio of p/t-PI3K, p/t-AMPK, p/t-p38MAPK, p/t-Akt, p/t-mTOR, p/t-Erk1/2, PTEN, beclin 1, and LC3-II/I in BxPC-3 cells. Data represent the mean ± SD of three independent experiments. *P<0.05 and **P<0.01 by one-way ANOVA.

Abbreviations: ALS, alisertib; PI3K, phosphatidylinositol 3-kinase; AMPK, 5′-AMP-dependent kinase; MAPK, mitogen-activated protein kinase; Akt, protein kinase B; mTOR, mammalian target of rapamycin; Erk, extracellular signal-regulated kinase; PTEN, phosphatase and tensin homolog; LC3, light chain 3; SD, standard deviation; ANOVA, analysis of variance.