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. 2015 Jan 17;9:537–560. doi: 10.2147/DDDT.S73689

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© 2015 Wang et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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PLB regulates the expression of CDK1/CDC2, cyclin B1, cyclin D1, p21 Waf1/Cip1, p27 Kip1, and p53 in PANC-1 and BxPC-3 cells.

Notes: Cells were treated with PLB at concentrations of 0.1, 1, and 5 μM for 24 hours and then protein samples of cells were subjected to Western blotting assay. (A) Representative blots for CDK1/CDC2, cyclin B1, cyclin D1, p21 Waf1/Cip1, p27 Kip1, and p53, and (B) bar graphs showing the relative expression level of CDK1/CDC2, cyclin B1, cyclin D1, p21 Waf1/Cip1, p27 Kip1, and p53 in PANC-1 and BxPC-3 cells. Data are the mean ± SD. *P<0.05, **P<0.01, and ***P<0.001 by one-way ANOVA.

Abbreviations: ANOVA, analysis of variance; Conc, concentration; PLB, plumbagin; SD, standard deviation.