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. Author manuscript; available in PMC: 2016 Feb 20.
Published in final edited form as: Mol Biosyst. 2014 Nov 24;11(2):338–353. doi: 10.1039/c4mb00627e

Figure 10. Representative lipase enzymes involved in amide bond synthesis.

Figure 10

(A) Aminolysis of the methyl ester of acetoacetate using allyl- and benzyl-amines and hydroxylamine acceptors resulting in high product yields. (B) CalB-catalyzed transformation of triolein (olive oil) to its corresponding oleamide via ammonialysis, i.e., direct utilization of ammonia as the nucleophile. (C) The synthesis of lactams by intramolecular aminolysis with amino-alkanoic esters. (D) The synthesis of macrocyclic bislactams by inter/intramolecular aminolysis of diamines and diesters. (E) Lipase-mediated transamidation reaction with a highly activated N-2,2,2-trifluoroethyl-2-chloropropionamide donor. (F) Amidation of oleic acid using taurine as the acyl acceptor.