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. 2014 Dec 17;11:218. doi: 10.1186/s12985-014-0218-8

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© Angelova et al.; licensee BioMed Central. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Effect of β-catenin knockdown on tubule formation and β-catenin target gene expression. HUVECs expressing vGPCR were transiently transfected with siRNA to β-catenin or with non-silencing siRNA control. (A) 72 hr following β-catenin silencing, knockdown efficiency was determined by qRT-PCR. β-catenin mRNA levels were normalized to 36B4 expression. (B) vGPCR-HUVECs were plated on Matrigel as described in Materials and Methods and allowed to form tubules. (C) The number of branch points was determined 6 hr after plating. The data is presented as an average of two independent experiments performed in duplicate. ***p < 0.001.