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. 2015 Jan 20;8:34. doi: 10.1186/s13071-014-0622-3

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© Wheeler et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Comparative effects of pharmacological inhibition on motility. A-C) Pharmacological inhibition of three putative targets via available chemical inhibitors leads to correlative motility phenotype in free-living (G. tigrina) and parasitic flatworms (S. mansoni). Chemical inhibitors of ARPC2 (A) and SDH1 (B) caused a dose-dependent decrease in motility in both species as measured by contractions per second (schistosomula) or millimeters of translational movement per second (planaria). Chemical inhibitor of NDUFV2 (C) did not have any dose-dependent effects in either organism. Nonlinear regression is fit to a four-parameter variable slope model; log(inhibitor) vs. response. Bars represent SEM from the combination of two experiments.