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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: J Am Coll Surg. 2014 Nov 6;220(2):243–253. doi: 10.1016/j.jamcollsurg.2014.11.001

Table 4.

MicroRNAs Associated with Various Histologic Classifications of Intraductal Papillary Mucinous Neoplasms

Histologic classification of IPMN First author Tissue Source Up-regulated Down-regulated
Lesion
    Non-invasive IPMN Habbel97, Caponi94,
Nakhara98 		Tissue miR-21, miR-155,
miR-107, miR-223,
miR-181c, miR-181a,
miR-221, miR-210,
miR-16, miR-100		 miR-101
Li99 Serum miR-1290 --
    Invasive IPMN Lubezky95,
Caponi94, He100 		Tissue miR-21, miR-155,
miR-708		 miR-101, miR-217,
miR-218
    PDAC vs non-invasive IPMN Lee101 Tissue miR-21-5p, miR-708 miR-485-3p, miR-
375
Jiao102 Tissue miR-16, miR-126
Li99 Serum miR-1290 --
Degree of dysplasia
    HG IPMN Lubezky95, Habbe97 Tissue miR-10a, miR-21,
miR-146, miR-155		 --
    IG IPMN Lubezky95, Habbe97 Tissue miR-21, miR-155,
miR-708		 miR-217
    LG IPMN Lubezky95, Habbe97 Tissue miR-21, miR-155,
miR-708		 miR-217
    HG/Invasive IPMN vs LG/IG
    IPMN		 Lubezky95 Tissue miR-21, miR-146a,
miR-150, miR-214,
miR-503, miR-424,
miR-708, miR-155		 miR-217, miR-216a,
miR-216b, miR-148,
miR-375, miR-130b
Matthei96 Tissue, cyst fluid miR-18a, miR-24,
miR-30a-3p, miR-
92a, miR-99b miR-
106b, miR-142-3p,
miR-342-3p, miR-
532-3p		 DiffPairs analysis
    LG IPMN vs HG IPMN with
    evidence of invasion		 Lubezky96 Tissue miR-10a, miR-21,
miR-24-2, miR-132,
miR-146a, miR-146b,
miR-155, miR-196,
miR-424, miR-503,
miR-708		 miR-217, miR-216a,
miR-216b, miR-148,
miR-375, miR-130b
IPMN morphological subtype
    Intestinal Aso103, Habbe97 Tissue, serum miR-196a, miR-21,
miR-155		 --
    Gastric Habbe97 Tissue -- miR-155

IPMN, intraductal papillary mucinous neoplasm; HG, high grade; IG, intermediate grade; LG, low grade; PDAC, pancreatic ductal adenocarcinoma.