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. 2015 Jan 23;10(1):e0117513. doi: 10.1371/journal.pone.0117513

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Fig 2 — (A) mfap4 RNA expression at 2 dpf shows a complete loss of macrophages in irf8 mutant but abundant macrophages in heterozygous sibling (arrows). (B) mpx RNA expression at 2 dpf shows an overproduction of neutrophils in irf8 mutants (arrows, bottom panels) compared with the sibling (arrow, top panels). Right column in A and B shows a higher magnification image of the trunk region from the same embryos depicted in the left column. (C) Neutrophils can first be detected on the yolk sac by 1 dpf. irf8 mutants have many yolk sac neutrophils (arrows) compared with sibling. (D) At 2 dpf, irf8 mutants continue to have more neutrophils on the yolk sac (arrows). Overall, irf8 mutants appear to have more neutrophils throughout the body. All scale bars are 100 um.