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. 2015 Jan 23;10(1):e0117513. doi: 10.1371/journal.pone.0117513

Fig 6. Summary model for role of irf8 in macrophage ontogeny in zebrafish.

Fig 6

irf8 is required for development of all macrophages in the early developmental period until 5–6 dpf (solid orange bar). Coinciding with the onset of the adult phase hematopoiesis in the kidney starting at ~7 dpf, hematopoiesis relies on irf8 and other factors for macrophage specification and differentiation (dotted orange bar). RBI, rostral blood island; PBI, posterior blood island; CHT, caudal hematopoietic tissue; AGM, aorta-gonad-mesonephros analog; hpf, hours postfertilization; dpf, days postfertilization.