Table 2.
Summary of experimental SHFV infection studies.
| Animal ID# | Virus infection: 100 plaque forming units (PFU) intravenously | Prothrombin time (PT) seconds (pre-infection) | Prothrombin time (PT) seconds (euthanasia) | Activated partial thromboplastin time (PTT) seconds (pre-infection) | Activated partial thromboplastin time (PTT) seconds (euthanasia) | Survival (days) post-SHFV infection | Clinical signs |
|---|---|---|---|---|---|---|---|
| Cohort 1 | |||||||
| JM-23333 | SHFV B11661 | NA | NA | NA | NA | 7 | Fever, lethargy, anorexic, increased respiratory rate |
| JM-24054 | SHFV B11661 | NA | NA | NA | NA | 13 | Fever, diarrhea, scrotal edema, petechiae, epistaxis, |
| Cohort 2 | |||||||
| JM-22015 | SHFV B11661 | 10.5 | 23.0 | 29.4 | 48.8 | 9 | Fever, petechiae and periocular and scrotal edema |
| JM-23328 | SHFV B11661 | 11.5 | 19.5 | 32.4 | 54.8 | 9 | Fever, petechiae and periocular edema |