Figure 6.

Anterior to posterior coronal brain sections from the Sf-1^TauGFP mouse (A,C,E,G,I,K) and the Z/EG^Sf1:Cre reporter mouse (B,D,F,H,J,L) at E 17.5. A,B: Fibers are seen surrounding, but sparing, the suprachiasmatic nucleus (SCN) in both mouse models. Hypothalamic paraventricular nucleus (PVH) and the anterior hypothalamus (AH) also receive fiber projections. The vsoc is the major fiber tract and travels laterally and dorsally. C,D: Fine fiber tracts are seen projecting toward the HN and the PVH. E,F: Fibers projecting from the dorsolateral region of the VMH join the vsoc at the lateral aspect of the medial lemniscus (ml). Midline fibers travel through the dorsomedial hypothalamic nucleus (DMH) to terminate in the periaqueductal gray (PAG), whereas lateral fibers fanning out from the vsoc travel through the medial geniculate nucleus (MGN). Arrows point to the ventrolateral region of the VMH (VMH_vl), where GFP⁺ neurons are present in the Z/EG^Sf1:Cre reporter mouse but not the Sf-1^TauGFP mouse. G–J: GFP⁺ neurons in the VMH_vl are absent in the Sf-1^TauGFP mouse (G,I) but present in the Z/EG^Sf1:Cre mouse (H,J). Fibers travel through the posterior hypothalamus (PH) and the DMH medially and the MGN laterally. K,L: Fibers can be seen in the PAG and deeper layer of the superior colliculus (SC). For abbreviations see list. Scale bars = 0.5 mm.