Figure 3. Consequential SNVs in high-likelihood driver genes only occur in carcinogen-induced tumours.

All missense and nonsense SNVs, amplifications, and deletions in genes listed in Extended Data Table 2 are displayed. Kras^LA2, urethane-, and MNU-induced tumours are denoted above in green, blue, and red, respectively, with lighter shading denoting Kras^+/− genotype. SNVs with unequivocal evidence of consequence are bordered in black. All SNVs, excepting those marked with an asterisk, are concordant with the signature mutations of the inducing carcinogen. The bottom panel shows total SNVs per tumour (NS = nonsynonymous, S = synonymous).