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. Author manuscript; available in PMC: 2015 Jul 22.
Published in final edited form as: Nature. 2014 Nov 2;517(7535):489–492. doi: 10.1038/nature13898

Figure 4. Adenocarcinomas show enrichment for a signature of genomic instability.

Figure 4

Breakdown of G>A transitions in A/J and FVB/N adenocarcinomas reveals significant increases in CGN>A (NCG>T) transition rates over FVB/N adenomas (p = 0.00047 and 0.0143, respectively, Wilcoxon rank-sum), despite similar rates and patterns of other G>A transitions. Mutation counts per tumour were normalized to total length of sequenced trinucleotide contexts in each tumour and averaged. Error bars represent SEM.