Table 3. Associations of IL17A polymorphisms with premature CAD.
| Polymorphism | Alleles* | MAFa
|
MAFa
|
Genotypes |
Genotypes |
Phwe
|
OR (95% CI) |
|---|---|---|---|---|---|---|---|
| CAD | Control | Premature CAD | Control | CAD/Control | Pdom value | ||
| rs8193036 | T/C | 0.21 | 0.22 | 546/303/46 | 409/221/34 | 0.63/0.57 | 0.99 (0.77–1.26); 0.91 |
| 0.61/0.34/0.05 | 0.61/0.33/0.05 | ||||||
| rs3819024 | A/G | 0.17 | 0.19 | 615/259/24 | 434/209/24 | 0.72/1.00 | 0.87 (0.68–1.12); 0.29 |
| 0.68/0.28/0.03 | 0.65/0.31/0.04 | ||||||
| rs2275913 | G/A | 0.16 | 0.19 | 616/259/23 | 439/202/26 | 0.55/0.62 | 0.91 (0.70–1.17); 0.44 |
| 0.69/0.29/0.03 | 0.66/0.30/0.04 | ||||||
| rs8193037 | G/A | 0.08 | 0.07 | 763/126/9 | 578/83/6 | 0.13/0.17 | 1.14 (0.81–1.59); 0.46 |
| 0.85/0.14/0.01 | 0.87/0.12/0.01 |
Adjusted for age, gender, BMI, hypertension, diabetes mellitus, smoking history, TC, HDL-C, LDL-C and triglycerides.
a: MAF, minor allele frequency.
CAD: Coronary artery disease.
Phwe: p value from Hardy-Weinberg equilibrium tests.
NS: Not significant.
*Underlined letter denotes the minor allele in the control samples.
Only the dominant model is showed.