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. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: Nat Struct Mol Biol. 2014 Nov 24;21(12):1058–1067. doi: 10.1038/nsmb.2922

Figure 3. Structural Analysis of the 4E10 Fab–SAH-MPER(671-683KKK)(q) Complex.

Figure 3

(a) Crystal structure of SAH-MPER(671-683KKK)(q) (shown as a blue ribbon and gray transparent van der Waals surface) bound to 4E10 Fab at 2.9 Å resolution. (b) 2Fo-Fc electron density map (1σ level) of the antibody-bound SAH-MPER(671-683KKK)(q) peptide. (c) Superimposition of the native (green, 2FX7)18 and i, i+3-stapled (gray) MPER(671-683KKK) peptides highlights the similarity of antibody-bound structures, aside from the appended C-terminal lysines and the incorporated staple. Z and X represent R3 and S5, respectively.