Table 4.

18-month changes in log-adjusted inflammatory biomarker parameter estimates and 95% confidence intervals, per unit change in measures of body adiposity, for individual undergoing intentional weight loss, only.

Change in body mass and adiposity measures	Δ Log-Adjusted CRP (mg/L)				Δ Log-Adjusted IL-6 (pg/mL)
	Estimate	95% CI	p-value	AIC*	Estimate	95% CI	p-value	AIC*
Δ Total body mass (kg)	0.05	(0.03,0.06)	<0.01	266.7	0.02	(0.01,0.02)	<0.01	184.0
Δ BMI (kg/m2)	0.15	(0.11,0.19)	<0.01	265.3	0.05	(0.03,0.08)	<0.01	182.2
Δ Total body fat mass (kg)	0.06	(0.04,0.08)	<0.01	271.2	0.02	(0.01,0.04)	<0.01	181.3
Δ Percent body fat (%)	0.08	(0.05,0.11)	<0.01	276.8	0.03	(0.01,0.05)	<0.01	182.9
Δ Total abdominal fat volume (per 1000 cm3)	0.37	(0.24,0.51)	<0.01	271.1	0.19	(0.11,0.28)	<0.01	191.4
Δ Abdominal visceral fat volume (per 1000 cm3)	0.79	(0.50,1.08)	<0.01	269.7	0.35	(0.15.0.55)	<0.01	193.3
Δ Abdominal subcutaneous fat volume (per 1000 cm3)	0.57	(0.33,0.80)	<0.01	276.5	0.33	(0.18,0.48)	<0.01	189.2
Δ Abdominal intermuscular fat volume (per 1000 cm3)	5.00	(0.66,9.34)	0.02	284.8	2.75	(0.02,5.49)	0.05	191.0
Δ Total thigh fat volume (per 1000 cm3)	0.88	(0.26,1.49)	<0.01	288.1	0.21	(−0.20,0.61)	0.31	195.4
Δ Thigh intermuscular fat volume (per 1000 cm3)	6.31	(−4.14,16.76)	0.23	286.9	3.61	(−2.99,10.20)	0.28	189.7
Δ Thigh subcutaneous fat volume (per 1000 cm3)	0.94	(0.29,1.59)	<0.01	287.8	0.21	(−0.21,0.64)	0.32	195.3

Results presented for the D and D+E arms, only. Model estimates adjust for randomization group, race, gender, age and baseline outcome measure. CT-derived measures of adiposity are expressed per 1000 cm³.

^*Akike’s Information Criteria (AIC) estimates are calculated among participants with baseline and follow-up weight, BMI, DXA, and CT measures (n=98).