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. 2015 Jan 8;22(6):755–764. doi: 10.1111/wrr.12238

Table 1.

Characteristics of human and murine hypertrophic scars

Parameter Human HSc Murine HSc
Initial injury Burn Third-degree burn Third-degree burn
Management Surgical Excision and skin graft Excision and skin graft
Gross appearance Scar contraction Increased Increased
Matrix Collagen maturation/type I Increased Increased
Cellularity Vascularity Increased Increased
Macrophage density Increased Increased
Mast cell density Increased Increased
Proliferation Increased Increased
Cytokines TGF-β Increased Increased
Cytoskeletal changes ASMA Increased Increased
NMMIIA Increased Increased
ROCK2 Increased Increased
Elasticity Elastic modulus Increased compared with uninjured human skin Increased compared with uninjured mouse skin

ASMA, alpha smooth muscle actin; HSc, hypertrophic scar contraction; NMMIIA, nonmuscle myosin II A; ROCK2, rho-associated protein kinase; TGF-β, transforming growth factor beta.