Table 1.
Characteristics of human and murine hypertrophic scars
Parameter | Human HSc | Murine HSc | |
---|---|---|---|
Initial injury | Burn | Third-degree burn | Third-degree burn |
Management | Surgical | Excision and skin graft | Excision and skin graft |
Gross appearance | Scar contraction | Increased | Increased |
Matrix | Collagen maturation/type I | Increased | Increased |
Cellularity | Vascularity | Increased | Increased |
Macrophage density | Increased | Increased | |
Mast cell density | Increased | Increased | |
Proliferation | Increased | Increased | |
Cytokines | TGF-β | Increased | Increased |
Cytoskeletal changes | ASMA | Increased | Increased |
NMMIIA | Increased | Increased | |
ROCK2 | Increased | Increased | |
Elasticity | Elastic modulus | Increased compared with uninjured human skin | Increased compared with uninjured mouse skin |
ASMA, alpha smooth muscle actin; HSc, hypertrophic scar contraction; NMMIIA, nonmuscle myosin II A; ROCK2, rho-associated protein kinase; TGF-β, transforming growth factor beta.