Table 1.
Characteristics of human and murine hypertrophic scars
| Parameter | Human HSc | Murine HSc | |
|---|---|---|---|
| Initial injury | Burn | Third-degree burn | Third-degree burn |
| Management | Surgical | Excision and skin graft | Excision and skin graft |
| Gross appearance | Scar contraction | Increased | Increased |
| Matrix | Collagen maturation/type I | Increased | Increased |
| Cellularity | Vascularity | Increased | Increased |
| Macrophage density | Increased | Increased | |
| Mast cell density | Increased | Increased | |
| Proliferation | Increased | Increased | |
| Cytokines | TGF-β | Increased | Increased |
| Cytoskeletal changes | ASMA | Increased | Increased |
| NMMIIA | Increased | Increased | |
| ROCK2 | Increased | Increased | |
| Elasticity | Elastic modulus | Increased compared with uninjured human skin | Increased compared with uninjured mouse skin |
ASMA, alpha smooth muscle actin; HSc, hypertrophic scar contraction; NMMIIA, nonmuscle myosin II A; ROCK2, rho-associated protein kinase; TGF-β, transforming growth factor beta.