TABLE I.
Cell line | All ESC clusters |
All EpiSC clusters |
ESC-specific clusters |
EpiSC- specific clusters |
ESC/EpiSC shared Clusters |
---|---|---|---|---|---|
Biological Process | negative regulation of gene expression 0 |
embryo development 7.6E-278 |
protein complex subunit organization 2.9E-134 |
embryonic morphogenesis 1.1E-64 |
regulation of cellular metabolic process 2.7E-285 |
chordate embryonic development 3.6E-319 |
negative regulation of gene expression 2.E-229 |
in utero embryonic development 1.5E-132 |
pattern specification process 4.20E-62 |
regulation of macromolecule metabolic process 2.1E-272 |
|
in utero embryonic development 8.3E-213 |
embryonic morphogenesis 2.4E-191 |
posttranscriptional regulation of gene expression 1.7E-105 |
regionalization 3.6E-54 |
regulation of gene expression 3.7E-239 |
|
Mouse Phenotype | prenatal lethality 0 |
abnormal embryonic tissue morphology 5.2E-287 |
prenatal growth retardation 2E-224 |
abnormal neuron differentiation 10E-45 |
prenatal lethality 6.5E-155 |
embryonic lethality 0 |
embryonic lethality during organogenesis 1.1E-253 |
decreased embryo size 1.04E-215 |
partial neonatal lethality 5.8E-40 |
abnormal embryogenesis/ development 1.9E-143 |
|
embryonic lethality between implantation and placentation 0 |
abnormal neural tube closure 7.8E-129 |
abnormal placenta morphology 1.85E-146 |
abnormal nervous system tract 7.1E-38 |
abnormal nervous system development 8.8E-117 |
|
Expression | TS4 inner cell mass 0 |
TS21_embryo; head 1.2E-283 |
TS4_inner cell mass 0 |
TS17_brain 2.4E-91 |
TS17_embryo 2E-298 |
TS4 extraembryonic component 0 |
TS17_limb 5.59E-272 |
TS4_extraembryonic component 0 |
TS15_embryo; mesenchyme 3.3E-63 |
Theiler_stage_19 1.1E-254 |
|
Theiler stage 3 0 |
TS3_4–8 cell stage 1.3E-253 |
Theiler stage 3 0 |
TS12_embryo 1.7E-57 |
TS23_metanephros 3.9E-240 |
|
Perturbation | Genes up-regulated in CD34+ cells isolated from bone marrow of CML 0 |
Genes with copy number losses in primary neuroblastoma tumors. 5.2E-204 |
Genes constituting the BRCA1-PCC network 0 |
'PRC2 targets': trimethylated H3K27 mark in their promoters and are bound by SUZ12 and EED 7.9E-86 |
'H3K27 bound': genes possessing the H3K27me3 mark in their promoters in human embryonic stem cells 8.5E-126 |
Set 'Nanog targets': genes in human embryonic stem cells. 0 |
Housekeeping genes identified as expressed across 19 normal tissues. 1.4E-120 |
Genes down-regulated in prostate cancer after knockdown of NIPP1 0 |
Genes with copy number gains in primary neuroblastoma tumors. 3.9E-26 |
Eed target genes in human embryonic stem cells 2.2E-106 |
|
Set 'Sox2 targets': genes in human embryonic stem cells 0 |
Genes up-regulated in lymphoblastoid cells 7.2E-105 |
Set 'Sox2 targets': genes in human embryonic stem cells 7.2E-268 |
Genes bearing H3K27me3 mark or bound by SUZ12 or EED 4.8E-19 |
'PRC2 targets': trimethylated H3K27 mark in their promoters and are bound by SUZ12 and EED 4E-97 |