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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: J Neurochem. 2014 Sep 18;132(3):354–366. doi: 10.1111/jnc.12936

Fig. 6. Proposed mechanism of action.

Fig. 6

HIV-1 Tat interacts with LRP leading to Src-dependent potentiation of the NMDAR and activation of the NOS/sGC/PKG signaling pathway. PKG activates a RhoA/ROCK signaling pathway leading to remodeling of the actin cytoskeleton and subsequent reduction of NMDAR function.