Table 2. Outcome risk among statin-users in comparison to non-users.
| Non-users n (%) |
Statin-users n (%) |
OR (95% CI) | |
|---|---|---|---|
| Propensity score-matched cohort | |||
| Benign prostatic hypertrophy | 1,030 (31.2) | 1,082 (32.8) | 1.08 (0.97 – 1.19) |
| Erectile dysfunction | 762 (23.1) | 765 (23.2) | 1.01 (0.90 – 1.13) |
| Infertility | 18 (0.5) | 22 (0.7) | 1.22 (0.66 – 2.29) |
| Testicular dysfunction | 171 (5.2) | 157 (4.8) | 0.91 (0.73 – 1.14) |
| Psychosexual dysfunction | 801 (24.3) | 815 (24.7) | 1.02 (0.92 – 1.15) |
| All psycho-gonadism disorders | 1,210 (36.6) | 1,235 (37.4) | 1.03 (0.94 – 1.14) |
| Overall cohort (adjusting for propensity score) | |||
| Benign prostatic hypertrophy | 2,112 (16.5) | 3,263 (41.1) | 1.08 (0.99 – 1.19) |
| Erectile dysfunction | 1,719 (13.4) | 2,049 (25.8) | 1.08 (0.97 – 1.20) |
| Infertility | 180 (1.4) | 28 (0.4) | 1.25 (0.80 – 1.96) |
| Testicular dysfunction | 463 (3.6) | 478 (6.0) | 1.05 (0.87 – 1.27) |
| Psychosexual dysfunction | 2,314 (18.1) | 2,001 (25.2) | 1.06 (0.96 – 1.17) |
| All psycho-gonadism disorders | 3,334 (26.1) | 3,178 (40.0) | 1.10 (1.01 – 1.20) |
| No Charlson comorbidities cohort (adjusting for propensity score) | |||
| Benign prostatic hypertrophy | 1,527 (14.1) | 1,224 (34.6) | 1.21 (1.08 – 1.35) |
| Erectile dysfunction | 1,291 (11.9) | 797 (22.5) | 1.08 (0.95 – 1.22) |
| Infertility | 164 (1.5) | 20 (0.6) | 1.34 (0.81 – 2.21) |
| Testicular dysfunction | 355 (3.3) | 179 (5.1) | 1.07 (0.85 – 1.36) |
| Psychosexual dysfunction | 1,865 (17.2) | 881 (24.9) | 1.05 (0.93 – 1.18) |
| All psycho-gonadism disorders | 2,635 (24.4) | 1,319 (37.2) | 1.11 (0.99 – 1.22) |
|
| |||
| Overall cohort limiting statin-users to those who used statins for ≥ 2 years (adjusting for propensity score) | |||
|
| |||
| Benign prostatic hypertrophy | 2,112 (16.5) | 3,007 (42.7) | 1.10 (0.99 – 1.22) |
|
| |||
| Erectile dysfunction | 1,719 (13.4) | 1,845 (26.2) | 1.06 (0.95 – 1.18) |
|
| |||
| Infertility | 180 (1.4) | 21 (0.3) | 1.33 (0.80 – 2.21) |
|
| |||
| Testicular dysfunction | 463 (3.6) | 424 (6.0) | 1.03 (0.84 – 1.23) |
|
| |||
| Psychosexual dysfunction | 2,314 (18.1) | 1,771 (25.1) | 1.02 (0.92 – 1.13) |
|
| |||
| All psycho-gonadism disorders | 3,334 (26.1) | 2,836 (40.3) | 1.08 (0.99 – 1.19) |
|
| |||
| Overall cohort limiting statin-users to those who used statins for ≥ 4 years (adjusting for propensity score) | |||
|
| |||
| Benign prostatic hypertrophy | 2,112 (16.5) | 2,490 (45.0) | 1.11 (1.00 – 1.24) |
|
| |||
| Erectile dysfunction | 1,719 (13.4) | 1,441 (26.1) | 0.94 (0.83 – 1.06) |
|
| |||
| Infertility | 180 (1.4) | 15 (0.3) | 1.52 (0.84 – 2.75) |
|
| |||
| Testicular dysfunction | 463 (3.6) | 321 (5.8) | 0.92 (0.74 – 1.15) |
|
| |||
| Psychosexual dysfunction | 2,314 (18.1) | 1,354 (24.5) | 0.91 (0.81 – 1.02) |
|
| |||
| All psycho-gonadism disorders | 3,334 (26.1) | 2,199 (39.8) | 0.97 (0.88 – 1.07) |
CI=confidence interval; OR=odds ratio
Note: bold italics indicates statistical significance