Table III.

Estimated Least Squares Means (LSM) comparing the change in HRQL over time, from baseline to exit, between transfusion and observation groups

		Transfusion		Observation		Est.	95% CI [Lower, Upper]	P
		Baseline LSM	Exit LSM	Baseline LSM	Exit LSM
Primary Outcome	Change in health	3.44	4.30	3.50	3.82	−0.54	[−0.92, −0.17]	0.00
Secondary Outcomes	Global health	65.70	68.29	63.30	66.00	0.11	[−7.52, 7.73]	0.98
	Global behavior	79.37	68.29	75.59	77.67	5.84	[−1.73, 13.42]	0.13
	Family cohesion	79.05	75.53	78.61	78.81	3.72	[−3.39, 10.83]	0.30
	Physical function	82.98	88.67	76.75	76.90	−5.54	[−13.37, 2.29]	0.16
	Role-emotion	82.87	84.06	74.53	81.76	6.05	[−3.71, 15.80]	0.22
	Role-physical	80.06	87.88	77.30	81.31	−3.82	[−13.84, 6.21]	0.45
	Bodily pain	73.18	78.51	66.21	67.56	−3.98	[−12.85, 4.89]	0.38
	Behavior	72.80	74.49	71.91	75.02	1.42	[−4.37, 7.20]	0.63
	Mental health	75.93	79.86	76.43	78.25	−2.10	[−7.31, 3.11]	0.43
	Self esteem	84.01	82.24	84.34	79.34	−3.22	[−8.73, 2.29]	0.25
	General health	46.45	51.60	47.12	48.68	−3.59	[−8.71, 1.53]	0.17
	Parental Impact-Emotional	57.86	65.94	63.22	66.04	−5.26	[−15.52, 5.01]	0.31
	Parent time	75.41	78.83	74.51	76.67	−1.27	[−11.53, 9.00]	0.81
	Family-Limitations in Activities	72.92	79.16	73.08	76.40	−2.93	[−10.17, 4.31]	0.43
	Physical summary	41.04	46.06	38.68	39.90	−3.79	[−7.99, 0.42]	0.08
	Psychosocial summary	48.96	50.08	49.33	50.24	−0.22	[−3.44, 3.01]	0.89

CI, confidence interval; Est., Difference estimate.