Table 1.
−30 Minutes | + 5 minutes | +95 minutes | |||||||
---|---|---|---|---|---|---|---|---|---|
| |||||||||
F Phase | L Phase | p-value | F Phase | L Phase | p-value* | F Phase | L Phase | p-value** | |
Acute Spray Responses | |||||||||
Stimulated | 50.5 (2.5) | 47.6 (2.6) | 0.2145 | 58.5 (2.3) | 61.9 (2.4) | 0.0111 | 56.6 (2.3) | 61.0 (2.5) | 0.5415 |
Head Rush | 11.1 (1.7) | 9.7 (1.8) | 0.5133 | 34.9 (2.9) | 36.2 (3.1) | 0.4328 | 34.8 (2.9) | 32.6 (3.1) | 0.2308 |
Jittery | 20.3 (2.6) | 22.9 (2.8 | 0.4167 | 29.4 (2.6) | 33.1 (2.8) | 0.7791 | 28.3 (2.7) | 34.5 (2.9) | 0.7580 |
Dizzy1 | 8.7 (1.6) | 9.9 (1.7) | 0.5226 | 25.8 (2.6) | 24.3 (2.7) | 0.3665 | 22.4 (2.5) | 22.1 (2.6) | 0.7157 |
Alert | 64.9 (2.1) | 62.0 (2.3) | 0.1814 | 66.8 (1.9) | 66.2 (2.0) | 0.4754 | 67.3 (2.0) | 66.2 (2.1) | 0.7325 |
Physical Symptoms2 | 4.3 (0.4) | 4.7 (0.5) | 0.3285 | 4.5 (0.4) | 5.0 (0.4) | 0.7441 | 6.1 (0.4) | 6.3 (0.4) | 0.3747 |
Abstinence Relief | |||||||||
Urge to Smoke | 64.4 (2.8) | 68.6 (3.0) | 0.1933 | 51.2 (3.1) | 48.1 (3.3) | 0.0167 | 47.3 (3.0) | 46.3 (3.2) | 0.3982 |
Craving3 | 4.0 (0.2) | 3.9 (0.2) | 0.5194 | 3.3 (0.2) | 3.2 (0.2) | 0.5510 | 2.9 (0.2) | 2.9 (0.2) | 0.5576 |
Withdrawal | 10.1 (0.6) | 9.5 (0.6) | 0.3115 | 7.9 (0.5) | 8.0 (0.5) | 0.1326 | 7.7 (0.5) | 8.5 (0.6) | 0.1018 |
Affect | |||||||||
Relaxed | 58.6 (2.6) | 60.9 (2.5) | 0.3819 | 61.3 (2.1) | 62.5 (2.2) | 0.7179 | 63.6 (2.2) | 64.1 (2.3) | 0.8713 |
Pleasant | 64.8 (2.2) | 64.2 (2.4) | 0.8241 | 64.4 (2.1) | 63.4 (2.2) | 0.8535 | 65.3 (2.1) | 65.0 (2.3) | 0.6734 |
Positive Affect | 19.2 (0.8) | 19.8 (0.8) | 0.3623 | 19.8 (0.8) | 20.2 (0.8) | 0.9340 | 20.1 (0.8) | 20.0 (0.8) | 0.2344 |
Negative Affect | 6.9 (0.5) | 6.7 (0.6) | 0.8051 | 5.2 (0.5) | 5.5 (0.5) | 0.5641 | 5.9 (0.5) | 6.8 (0.5) | 0.1869 |
Difference was assessed by the change in pre-nicotine administration value (−30) subtracted from the post-nicotine administration peak value (5 minutes).
Difference was assessed by the change in post administration peak value (5 minutes) subtracted from the post second dose administration (95 minutes).
Testing Period Effect: Week 1 < Week 2; p=0.0167;
Period Effect: Week 1 > Week 2; p=0.0037;
Order Effect: p=0.0056 [Looking at only Week 1: F Phase > L Phase, −0.8 (0.2) vs −0.0 (0.2), respectively, diff=−0.7 (0.3) p=0.0145]