Table 1.
Subjective Response (Mean ± Standard Error) to Nicotine Nasal Spray during Acute Smoking Abstinence by Menstrual Phase (n=140)
| −30 Minutes | + 5 minutes | +95 minutes | |||||||
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| F Phase | L Phase | p-value | F Phase | L Phase | p-value* | F Phase | L Phase | p-value** | |
| Acute Spray Responses | |||||||||
| Stimulated | 50.5 (2.5) | 47.6 (2.6) | 0.2145 | 58.5 (2.3) | 61.9 (2.4) | 0.0111 | 56.6 (2.3) | 61.0 (2.5) | 0.5415 |
| Head Rush | 11.1 (1.7) | 9.7 (1.8) | 0.5133 | 34.9 (2.9) | 36.2 (3.1) | 0.4328 | 34.8 (2.9) | 32.6 (3.1) | 0.2308 |
| Jittery | 20.3 (2.6) | 22.9 (2.8 | 0.4167 | 29.4 (2.6) | 33.1 (2.8) | 0.7791 | 28.3 (2.7) | 34.5 (2.9) | 0.7580 |
| Dizzy1 | 8.7 (1.6) | 9.9 (1.7) | 0.5226 | 25.8 (2.6) | 24.3 (2.7) | 0.3665 | 22.4 (2.5) | 22.1 (2.6) | 0.7157 |
| Alert | 64.9 (2.1) | 62.0 (2.3) | 0.1814 | 66.8 (1.9) | 66.2 (2.0) | 0.4754 | 67.3 (2.0) | 66.2 (2.1) | 0.7325 |
| Physical Symptoms2 | 4.3 (0.4) | 4.7 (0.5) | 0.3285 | 4.5 (0.4) | 5.0 (0.4) | 0.7441 | 6.1 (0.4) | 6.3 (0.4) | 0.3747 |
| Abstinence Relief | |||||||||
| Urge to Smoke | 64.4 (2.8) | 68.6 (3.0) | 0.1933 | 51.2 (3.1) | 48.1 (3.3) | 0.0167 | 47.3 (3.0) | 46.3 (3.2) | 0.3982 |
| Craving3 | 4.0 (0.2) | 3.9 (0.2) | 0.5194 | 3.3 (0.2) | 3.2 (0.2) | 0.5510 | 2.9 (0.2) | 2.9 (0.2) | 0.5576 |
| Withdrawal | 10.1 (0.6) | 9.5 (0.6) | 0.3115 | 7.9 (0.5) | 8.0 (0.5) | 0.1326 | 7.7 (0.5) | 8.5 (0.6) | 0.1018 |
| Affect | |||||||||
| Relaxed | 58.6 (2.6) | 60.9 (2.5) | 0.3819 | 61.3 (2.1) | 62.5 (2.2) | 0.7179 | 63.6 (2.2) | 64.1 (2.3) | 0.8713 |
| Pleasant | 64.8 (2.2) | 64.2 (2.4) | 0.8241 | 64.4 (2.1) | 63.4 (2.2) | 0.8535 | 65.3 (2.1) | 65.0 (2.3) | 0.6734 |
| Positive Affect | 19.2 (0.8) | 19.8 (0.8) | 0.3623 | 19.8 (0.8) | 20.2 (0.8) | 0.9340 | 20.1 (0.8) | 20.0 (0.8) | 0.2344 |
| Negative Affect | 6.9 (0.5) | 6.7 (0.6) | 0.8051 | 5.2 (0.5) | 5.5 (0.5) | 0.5641 | 5.9 (0.5) | 6.8 (0.5) | 0.1869 |
*
Difference was assessed by the change in pre-nicotine administration value (−30) subtracted from the post-nicotine administration peak value (5 minutes).
**
Difference was assessed by the change in post administration peak value (5 minutes) subtracted from the post second dose administration (95 minutes).
1
Testing Period Effect: Week 1 < Week 2; p=0.0167;
2
Period Effect: Week 1 > Week 2; p=0.0037;
3
Order Effect: p=0.0056 [Looking at only Week 1: F Phase > L Phase, −0.8 (0.2) vs −0.0 (0.2), respectively, diff=−0.7 (0.3) p=0.0145]