Table 3.
Risk of incident CHD for lipoprotein particle markers in 4,679 MESA participants are adjusted for non-lipid variables* + specified lipid measure(s)†. Results for each marker are presented as hazard ratios for individuals in 4th quartiles, using respective 1st quartiles as referents; 95% confidence intervals and P values are specified.
| Outcome |
† Lipid
adjustment |
ApoB | ApoB/ApoA-I | LDL-P | LDL-P/HDL-P |
|---|---|---|---|---|---|
| CHD 233 |
LDL-C |
1.99
(1.18, 3.36) 0.01 |
1.86
(1.21, 2.85) 0.005 |
1.75
(1.11, 2.75) 0.016 |
2.3
(1.49, 3.57) <0.001 |
|
|
|||||
| events | Non-HDL-C |
1.83
(1.01, 3.34) 0.048 |
1.72
(1.10, 2.70) 0.018 |
1.60 (0.98, 2.62) 0.06 |
2.25
(1.43, 3.55) <0.001 |
|
|
|||||
| TC/HDL-C | 1.48 (0.94, 2.32) 0.089 |
1.32 (0.81, 2.15) 0.27 |
1.36 (0.85, 2.17) 0.20 |
2.02
(1.19, 3.42) 0.009 |
|
|
|
|||||
| TC+ LDL-C + HDL-C + TG |
1.23 (0.63, 2.41) 0.55 |
1.12 (0.64, 1.98) 0.69 |
1.08 (0.62, 1.91) 0.78 |
1.76 (0.95, 3.27) 0.072 |
|
Adjusted for non-lipid risk factors including sex, hypertension meds, systolic blood pressure, age (category), diabetes, smoking, and race/ethnicity.
CHD = coronary heart disease; TC = total cholesterol; LDL-C = low density lipoprotein cholesterol; HDL-C = high density lipoprotein cholesterol; TG = triglycerides; ApoB = apolipoproteins B-100; ApoA-I = apolipoprotein A-I; LDL-P = LDL particle; HDL-P = HDL particle; MESA = Multi-ethnic Study of Atherosclerosis