Table 3.

Cox Proportional Hazards Multivariable Analysis of Clinicopathologic Variables and Predictors of Overall and Disease-Specific Survival for Synovial Sarcoma Patients Undergoing Surgery, (N=1,189)

Variable (Predictor)	Hazard Ratio for Overall Survival in Synovial Sarcoma Patients (95% Confidence Interval)	P value	Hazard Ratio for Disease-Specific Survival in Synovial Sarcoma Patients (95% Confidence Interval)	P value
Age at Diagnosis	*1.02 (1.01–1.03)	P<0.001	1.01 (0.99–1.02)	P=0.391
Male	*1.63 (1.22–2.17)	P<0.001	*1.73 (1.27–2.35)	P<0.001
Race     White     Black     Asian or Pacific Islander     Other	1.00 (referent) 2.14 (1.43–3.22) 0.83 (0.43–1.59) 0.54 (0.07–3.94)	P=0.002	1.00 (referent) 2.43 (1.61–3.67) 0.66 (0.31–1.41) 0.66 (0.09–4.92)	P<0.001
Anatomic Site     Extremity     Head & Neck     Thoracic     Trunk     Abdominal	1.00 (referent) 1.88 (1.09–3.24) 2.60 (1.54–4.38) 1.80 (1.25–2.58) 2.20 (0.78–6.17)	P<0.001	1.00 (referent) 1.71 (0.94–3.13) 2.68 (1.52–4.72) 1.88 (1.28–2.76) 2.45 (0.87–6.91)	P<0.001
Grade     Low     Intermediate     High     Unknown	1.00 (referent) 0.83 (0.34–2.02) 0.95 (0.41–2.23) 0.73 (0.31–1.70)	P=0.412	1.00 (referent) 0.80 (0.30–2.13) 1.09 (0.43–2.76) 0.78 (0.31–1.96)	P=0.226
SEER Stage     Localized     Regional     Unstaged	1.00 (referent) 1.61 (1.19–2.19) 4.88 (2.31–10.3)	P<0.001	1.00 (referent) 1.83 (1.32–2.54) 3.73 (1.51–9.19)	P<0.001
Type of Surgery     Marginal     Ablation     Biopsy     Radical     Surgery NOS	1.00 (referent) 0.76 (0.46–1.24) 44.6 (8.91–223.3) 1.19 (0.86–1.64) 6.01 (2.06–17.5)	P<0.001	1.00 (referent) 0.74 (0.43–1.28) 30.2 (3.56 –256.8) 1.17 (0.83–1.65) 5.16 (1.53 –17.4)	P<0.001
Radiation     No     Yes	1.00 (referent) 0.65 (0.48 –0.88)	P=0.005	1.00 (referent) 0.62 (0.45–0.86)	P=0.003
Tumor Size in cm	*1.13 (1.10–1.16)	P<0.001	*1.13 (1.10–1.17)	P<0.001