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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: Cancer. 2014 Sep 23;121(3):467–475. doi: 10.1002/cncr.29065

Table 1.

Clinical features of 465 patients with Ewing sarcoma of bone according to mode of local control received.

Entire Cohort
(n = 465)		 Radiation
Alone
(n = 121)		 Surgery Alone
(n = 241)		 Radiation plus
Surgery
(n = 103)		 p-value*
Males 253 (54.4%) 64 (52.9%) 132 (54.8%) 57 (55.3%) 0.92
Mean age at diagnosis (range) 12.4 years
(0.7–33.0)		 13.3 years
(2.5–28.6)		 11.7 years
(0.7–33.0)		 13.1 years
(1–28.0)		 0.006
Age < 12 years 203 (43.7%) 46 (38.0%) 120 (49.8%) 37 (35.9%) 0.021
Tumor site
  Distal extremity
  Proximal extremity
  Pelvis
  Chest wall
Spine 		124 (26.7%)
123 (26.5%)
98 (21.1%)
95 (20.4%)
25 (5.4%)		 16 (13.2%)
22 (18.2%)
50 (41.3%)
15 (12.4%)
18 (14.9%)		 89 (36.9%)
80 (33.2%)
26 (10.8%)
45 (18.7%)
1 (0.4%)		 19 (18.5%)
21 (20.4%)
22 (21.4%)
35 (34.0%)
6 (5.8%)		 < 0.001
Tumor size
< 8 cm
≥ 8 cm 		77 (35.5%)
140 (64.5%)		 28 (41.2%)
40 (58.8%)		 39 (35.8%)
70 (64.2%)		 10 (25%)
30 (75%)		 0.24
Study
  INT-0091
  INT-0154
  AEWS0031 		152 (32.7%)
120 (25.8%)
193 (41.5%)		 62 (51.2%)
22 (18.2%)
37 (30.6%)		 59 (24.5%)
81 (33.6%)
101 (41.9%)		 31 (30.1%)
17 (16.5%)
55 (53.4%)		 < 0.001
Year on Study
  1988–1990
  1991–1993
  1994–1996
  1997–1999
  2000–2002
  2003–2005 		80 (17.2%)
72 (15.5%)
49 (10.5%)
71 (15.3%)
64 (13.8%)
129 (27.7%)		 36 (29.8%)
26 (21.5%)
8 (6.6%)
14 (11.6%)
16 (13.2%)
21 (17.4%)		 29 (12.0%)
30 (12.5%)
32 (13.3%)
49 (20.3%)
33 (13.7%)
68 (28.2%)		 15 (14.6%)
16 (15.5%)
9 (8.7%)
8 (7.8%)
15 (14.6%)
40 (38.8%)		 < 0.001
*

Unadjusted p-value. See Supplemental Table comparisons of baseline characteristics according to quintiles of surgical propensity score.