Skip to main content
. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Addict Biol. 2014 Jul 23;20(4):701–713. doi: 10.1111/adb.12166

Figure 4. Galnon has no effect on cocaine self-administration but attenuates cocaine-primed reinstatement.

Figure 4

Following the establishment of stable maintenance responding for cocaine on a FR1 schedule (maintenance values reflect an average of the last 3 days of maintenance sessions), subjects (n=8) were treated with vehicle or galnon (2 mg/kg, i.p.) 30 min prior to a self-administration session. Shown are the mean ± SEM of (A) active lever presses and reinforcers earned and (B) inactive lever presses during the 2-h test session. Lever pressing was then extinguished (extinction values reflect an average of the last 3 days of extinction), and rats were pretreated with vehicle or galnon (2 mg/kg, i.p.) 30 min prior to a cocaine-primed (10 mg/kg, i.p., n=7) or saline-primed (n=5) reinstatement test. Shown are the mean ± SEM active and inactive lever responses during the 2-h saline-primed (C and D) and cocaine-primed (E and F) sessions. ***p<0.001 compared to extinction, ##p<0.01 compared to vehicle.