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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Addict Biol. 2014 Jul 23;20(4):701–713. doi: 10.1111/adb.12166

Figure 5. Galnon has no effect on food self-administration but attenuates food-primed reinstatement.

Figure 5

Following the establishment of stable maintenance responding for food pellets on a FR1 schedule (maintenance values reflect an average of the last 3 days of maintenance sessions), subjects (n=10) were treated with vehicle or galnon (2 mg/kg, i.p.) 30 min prior to a self-administration session. Shown are the mean ± SEM of (A) active lever presses and reinforcers earned and (B) inactive lever presses during the 1-h test session. Lever pressing was then extinguished (extinction values reflect an average of the last 3 days of extinction), and rats were pretreated with vehicle or galnon (2 mg/kg, i.p.) 30 min prior to another extinction session (n=6) or a food-primed reinstatement test (n=10). Shown are the mean ± SEM active and inactive lever responses during the 1-h extinction (C and D) and food-primed reinstatement (E and F) sessions. *p<0.05 compared to extinction, ***p<0.001 compared to extinction, #p<0.05 compared to vehicle.