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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: Clin Cancer Res. 2014 Jul 23;21(3):632–641. doi: 10.1158/1078-0432.CCR-13-3310

Figure 4. Genomic alterations with translational or clinical relevance by HPV status.

Figure 4

(A) Shown is the incidence of selected potentially targetable and their association with key pathways in HPV(−) and HPV(+) samples.(B) Gene diagrams for a selection of key mutations in potentially targetable genes, or presumed driver genes. Shown are the genes domains that are affected by somatic mutations, the number of cases that harbor the respective mutation is indicated on the ordinate axis, the CHASM scores and p-values for each mutation (red = <0.5 CHASM score, which indicates predicted oncogenic driver character), as well prior reports of mutations based on occurrence in COSMIC, or prior publications.