Table 1.
Examples for three generations of hepatitis B vaccines
| Vaccine type | Manufacturer | Envelope antigen | Remarks |
|---|---|---|---|
| Plasma derived | Hepatavax-B® (Merck & Co.) | SHBs | HBsAg, 5–40 μg/dose, licensed worldwide (not in use) |
| Hevac B® (Pasteur M., France) | SHBsAg, (± MHBs) | HBsAg, 5–20 μg/dose, licensed in France (not in use) | |
| KGC® (Korea Green Cross) | SHBsa | HBsAg, licensed in East Asia | |
| Recombinant, yeast derived | RECOMBIVAX® HB (Merck & Co., USA) | SHBsa | HBsAg, small S, 2.5–10 μg/dose, licensed worldwide |
| Engerix-B® (GSK, Belgium) | SHBsa | HBsAg, small S, 10–20 μg/dose, licensed worldwide | |
| TGP 943™ (Takeda Chem, Japan) | SHBsa, MHBs | HBsAg (small S, Pre-S2) 10 μg/dose, licensed in Japan | |
| Recombinant, mammalian cell derived | Gen Hevac B® (Pasteur M, France)b | SHBs, MHBs | HBsAg (S, Pre-S2), 20 μg/dose, licensed in France |
| Sci-B-Vac/Bio-Hep-B™/Hepimmune™ (SciVac, Israel)c | SHBs, MHBs, LHBs | HBsAg, small S, Pre-S1, Pre-S2, 2.5–10 μg/dose, licensed in Israel and several countries in East Asia | |
| AG-3™ (Hepagene™) (Medeva, UK)c | SHBs, MHBs, LHBs | HBsAg, small S, Pre-S1, Pre-S2, 10–20 μg/dose, (not manufactured anymore) |
aSHBs-p24
bContain non-glycosylated p24 and glycosylated gp27, gp33, gp36
cContain non-glycosylated p24 and p39, and glycosylated gp27, gp33, gp36, gp42