Fig. 3.

Mipomersen metabolism is similar across species. a Schematic of mipomersen metabolism by nucleases [26]. b Intact mipomersen and its metabolites identified in urine by liquid chromatography–electrospray mass spectrometry [27]. c Representative chromatograms of urine samples collected from monkeys and humans treated with mipomersen. IS internal standard, MOE methoxyethyl, i.v. intravenous [27]