Fig. 4.

Exposure–response relationships between ISIS 301012 trough plasma concentrations and serum apoB levels (% baseline) in healthy human volunteers during and following six doses of mipomersen at 200 mg per injection. Trough plasma concentrations of ISIS 301012 were measured at ≥72 h from the last dose. Data are presented as mean ± standard error. Arrows represent dosing days. Reproduced from Yu et al. [5], with permission. apoB apolipoprotein B, i.v. intravenous infusion, s.c. subcutaneous injection