Table 6.
Clinical Cure and Microbiological Eradication, by Pathogen (Microbiologically Evaluable Analysis Set)
| Pathogen | HAP (excluding VAP), No. (%) |
VAP, No. (%) |
All Patients, No. (%) |
|||
|---|---|---|---|---|---|---|
| Ceftobiprole (n = 116) | Ceftazidime/Linezolid (n = 120) | Ceftobiprole (n = 46) | Ceftazidime/ Linezolid (n = 50) | Ceftobiprole (n = 162) | Ceftazidime/ Linezolid (n = 170) | |
| Staphylococcus aureus | 39 | 49 | 25 | 28 | 64 | 77 |
| Clinical cure | 28 (72) | 36 (73) | 9 (36) | 16 (57) | 37 (58) | 52 (68) |
| Microbiological eradication | 23 (59) | 31 (63) | 10 (40) | 18 (64) | 33 (52) | 49 (64) |
| MSSA | 20 | 30 | 17 | 19 | 37 | 49 |
| Clinical cure | 15 (75) | 24 (80) | 5 (29) | 10 (53) | 20 (54) | 34 (69) |
| Microbiological eradication | 15 (75) | 21 (70) | 5 (29) | 12 (63) | 20 (54) | 33 (67) |
| MRSA | 19 | 19 | 8 | 9 | 27 | 28 |
| Clinical cure | 13 (68) | 12 (63) | 4 (50) | 6 (67) | 17 (63) | 18 (64) |
| Microbiological eradication | 8 (42) | 10 (53) | 5 (63) | 6 (67) | 13 (48) | 16 (57) |
| Streptococcus pneumoniae | 7 | 14 | 4 | 1 | 11 | 15 |
| Clinical cure | 7 (100) | 13 (93) | 0 (0) | 1 (100) | 7 (64) | 14 (93) |
| Microbiological eradication | 7 (100) | 13 (93) | 0 (0) | 1 (100) | 7 (64) | 14 (93) |
| Enterobacteriaceae | 46a | 45b | 18 | 16 | 64 | 61 |
| Clinical cure | 33 (72) | 32 (71) | 5 (28) | 6 (38) | 38 (59) | 38 (62) |
| Microbiological eradication | 29 (63) | 32 (71) | 6 (33) | 7 (44) | 35 (55) | 39 (64) |
| Escherichia coli | 14 | 11 | 6 | 3 | 20 | 14 |
| Clinical cure | 8 (57) | 7 (64) | 2 (33) | 1 (33) | 10 (50) | 8 (57) |
| Microbiological eradication | 8 (57) | 7 (64) | 2 (33) | 1 (33) | 10 (50) | 8 (57) |
| Klebsiella pneumoniae | 12 | 19 | 4 | 4 | 16 | 23 |
| Clinical cure | 11 (92) | 15 (79) | 0 (0) | 1 (25) | 11 (69) | 16 (70) |
| Microbiological eradication | 10 (83) | 15 (79) | 0 (0) | 1 (25) | 10 (63) | 16 (70) |
| Enterobacter species | 9 | 7 | 3 | 2 | 12 | 9 |
| Clinical cure | 7 (78) | 3 (43) | 1 (33) | 0 (0) | 8 (75) | 3 (33) |
| Microbiological eradication | 6 (67) | 3 (43) | 2 (66) | 0 (0) | 8 (75) | 3 (33) |
| Proteus species | 5 | 5 | 2 | 5 | 7 | 10 |
| Clinical cure | 4 (80) | 2 (40) | 0 (0) | 1 (20) | 4 (57) | 3 (30) |
| Microbiological eradication | 3 (60) | 2 (40) | 0 (0) | 2 (40) | 3 (43) | 4 (40) |
| Serratia species | 5 | 4 | 3 | 3 | 8 | 7 |
| Clinical cure | 3 (60) | 2 (50) | 1 (33) | 3 (100) | 4 (50) | 5 (71) |
| Microbiological eradication | 2 (40) | 2 (50) | 1 (33) | 3 (100) | 3 (38) | 5 (71) |
| Pseudomonas aeruginosa | 16 | 20 | 11 | 14 | 27 | 34 |
| Clinical cure | 12 (75) | 14 (70) | 5 (45) | 10 (71) | 17 (63) | 24 (71) |
| Microbiological eradication | 9 (56) | 11 (55) | 4 (36) | 8 (57) | 13 (48) | 19 (56) |
| Acinetobacter baumannii | 8 | 12 | 6 | 5 | 14 | 17 |
| Clinical cure | 4 (50) | 9 (75) | 3 (50) | 4 (80) | 7 (50) | 13 (77) |
| Microbiological eradication | 4 (50) | 9 (75) | 3 (50) | 3 (60) | 7 (50) | 12 (71) |
| Haemophilus | 5 | 9 | 4 | 0 | 9 | 9 |
| Clinical cure | 2 (40) | 9 (100) | 1 (25) | na | 3 (33) | 9 (100) |
| Microbiological eradication | 2 (40) | 9 (100) | 1 (25) | na | 3 (33) | 9 (100) |
Numbers in bold refer to the number of patients with a pathogen in the respective group.
Abbreviations: HAP, hospital-acquired pneumonia; MRSA, methicillin-resistant Staphylococcus aureus; MSSA, methicillin-sensitive Staphylococcus aureus; n, number of patients with an outcome of clinical cure or eradication for the respective pathogen at test of cure; VAP, ventilator-associated pneumonia.
a Forty-six patients with Enterobacteriaceae isolated at baseline, including E. coli (monomicrobial), n = 11; E. coli plus Klebsiella spp, n = 1; E. coli plus Proteus spp, n = 1; E. coli plus Providencia spp, n = 1; K. pneumoniae (monomicrobial), n = 9; Klebsiella oxytoca, n = 1; K. pneumoniae plus Proteus spp, n = 1; K. pneumoniae plus Serratia spp, n = 1; K. pneumoniae plus Enterobacter spp, n = 1; Enterobacter spp, n = 8; Serratia spp, n = 5; Proteus mirabilis, n = 3; Citrobacter spp, n = 2; Providencia spp, n = 1.
b Forty-five patients with Enterobacteriaceae isolated at baseline, including E. coli (monomicrobial), n = 8; E. coli plus K. pneumoniae, n = 1; E. coli plus Proteus spp, n = 1; E. coli plus K. pneumoniae plus Serratia spp, n = 1; K. pneumoniae (monomicrobial), n = 14; Klebsiella oxytoca, n = 1; Klebsiella spp, n = 2; K. pneumoniae plus Proteus spp, n = 2; K. pneumoniae plus Proteus spp plus Serratia spp, n = 1; Enterobacter spp, n = 7; Serratia spp, n = 2; Proteus mirabilis, n = 3; Citrobacter spp, n = 1; Hafnia alvei, n = 1.