Table 2.

Non-imprinted genes highly expressed in the placenta.

locus	gene	description	mouse KO phenotypes	human growth phenotypes
7p12	IGFBP3	carrying protein for IGF1 and IGF2	retinal vessel loss [43]	implicated in common cancers [44]
12q23.2	IGF1	growth promoter	pre- and postnatal growth restriction, infertile [45]	pre- and postnatal growth restriction [46]
15q26.3	IGF1R	IGF1 and IGF2 receptor	fetal growth restriction and perinatal lethal	pre- and postnatal growth restriction [47]