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. 2015 Feb;185(2):536–549. doi: 10.1016/j.ajpath.2014.10.022

Figure 1.

Figure 1

Dynamin-like protein 1 (Dlp1) expression is decreased in the substantia nigra pars compacta (SNpc) of Parkinson disease (PD) patients. Western blot analysis (A) and densitometry (C) of the mitochondrial-enriched fraction of the SNpc from control patients (N = 4) and PD patients (N = 4) show decreased Dlp1 in mitochondria-enriched tissue (the units for molecular weight markers on the right of the Western blot are kDa). B: Fluorescent staining of Dlp1 (green) and glial fibrillary acidic protein (GFAP; red) in the SNpc of control patients and PD patients. Arrows point at Dlp1 and GFAP colocalization. D: Quantification of Dlp1 intensity in astrocytes from the SNpc of control (N = 6 cases, 109 cells) and PD patients (N = 6 cases, 118 cells). Data are presented as means ± SEM. ∗P < 0.05, ∗∗∗P < 0.001 by two-sided unpaired t-test. Scale bar = 20 μm (B).